Rubicon antibody (AA 241-271)

Catalog No. ABIN7872730

The Rabbit Polyclonal anti-Rubicon antibody (ABIN7872730) specifically detects Rubicon in WB, IF, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Rubicon antibody (AA 241-271) (ABIN7872730)

Target: Rubicon (KIAA0226) (KIAA0226)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Rubicon antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Rubicon Antibody

Binding Specificity: AA 241-271

Purpose: Rubicon Antibody / RUBCN / BARON

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 241-271 from the human protein was used as the immunogen for the Rubicon antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Rubicon antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Rubicon antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Rubicon

Target: Rubicon (KIAA0226) (KIAA0226)

Alternative Name: Rubicon

Background: Inhibits PIK3C3 activity, under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation. [UniProt]

UniProt: Q92622

Pathways: Autophagy