ITGA7 antibody (AA 247-279)

Catalog No. ABIN7872791

This Rabbit Polyclonal antibody specifically detects ITGA7 in WB, FACS, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ITGA7 antibody (AA 247-279) (ABIN7872791)

Target: ITGA7 (Integrin, alpha 7 (ITGA7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA7 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ITGA7 Antibody

Binding Specificity: AA 247-279

Purpose: Integrin alpha 7 Antibody / ITGA7

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 247-279 from the human protein was used as the immunogen for the Integrin alpha 7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Integrin alpha 7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Integrin alpha 7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ITGA7

Target: ITGA7 (Integrin, alpha 7 (ITGA7))

Alternative Name: Integrin alpha 7

Background: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

UniProt: Q13683

Pathways: Integrin Complex