PDE6B antibody (AA 25-237)

Catalog No. ABIN7872851

This Rabbit Polyclonal antibody specifically detects PDE6B in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PDE6B antibody (AA 25-237) (ABIN7872851)

Target: PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE6B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PDE6B Antibody

Binding Specificity: AA 25-237

Purpose: PDE6 beta Antibody / PDE6B

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids K25-Q237) was used as the immunogen for the PDE6 beta antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PDE6 beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PDE6 beta antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PDE6B

Target: PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))

Alternative Name: PDE6 beta

Background: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: P35913

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction