FGF23 antibody (AA 25-251)

Catalog No. ABIN7872856

The Mouse Monoclonal anti-FGF23 antibody (Clone FGF23-4169) (ABIN7872856) specifically detects FGF23 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for FGF23 antibody (AA 25-251) (ABIN7872856)

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGF23 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FGF23-4169

Product Details anti-FGF23 Antibody

Binding Specificity: AA 25-251

Purpose: FGF-23 Antibody / Fibroblast Growth Factor 23

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 25-251 was used as the immunogen for the FGF-23 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the FGF-23 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the FGF-23 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FGF23

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Alternative Name: FGF-23

Background: Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10 through FGF-23. Members of the FGF family share 30-55 % amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family, including four tyrosine kinases designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

UniProt: Q9GZV9

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion