RNASEH2A antibody (AA 25-299)

Catalog No. ABIN7872867

The Rabbit Polyclonal anti-RNASEH2A antibody is suitable to detect RNASEH2A in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for RNASEH2A antibody (AA 25-299) (ABIN7872867)

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEH2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-RNASEH2A Antibody

Binding Specificity: AA 25-299

Purpose: RNase H2 subunit A Antibody / RNASEH2A

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids R25-L299) was used as the immunogen for the RNase H2 subunit A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RNase H2 subunit A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RNase H2 subunit A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RNASEH2A

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Alternative Name: RNase H2 subunit A

Background: Ribonuclease H2 subunit A, also known as RNase H2 subunit A, is an enzyme that in humans is encoded by the RNASEH2A gene. The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.

UniProt: O75792