Metabotropic Glutamate Receptor 1 antibody (AA 25-466)

Catalog No. ABIN7872881

This Rabbit Polyclonal antibody specifically detects Metabotropic Glutamate Receptor 1 in WB, ELISA, IHC (p) and FACS. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for Metabotropic Glutamate Receptor 1 antibody (AA 25-466) (ABIN7872881)

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-Metabotropic Glutamate Receptor 1 Antibody

Binding Specificity: AA 25-466

Purpose: mGluR1 Antibody / GRM1

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids R25-E466) was used as the immunogen for the mGluR1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the mGluR1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the mGluR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Alternative Name: mGluR1

Background: The GRM1 gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q13255