CHGB antibody (AA 250-450)

Catalog No. ABIN7872901

The Mouse Monoclonal anti-CHGB antibody (Clone CHGB-7756) (ABIN7872901) specifically detects CHGB in IHC (p). The antibody is reactive with Human samples.

Quick Overview for CHGB antibody (AA 250-450) (ABIN7872901)

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CHGB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CHGB-7756

Product Details anti-CHGB Antibody

Binding Specificity: AA 250-450

Purpose: Chromogranin B Antibody / CHGB / Secretogranin I (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 250-450) from the human protein was used as the immunogen for the Chromogranin B antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Chromogranin B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Chromogranin B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CHGB

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Alternative Name: Chromogranin B

Background: Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A), chromogranin B (Chr-B, also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II), secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits Insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms, the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.

UniProt: P05060