BRSK2 antibody (AA 250-736)

Catalog No. ABIN7872927

The Rabbit Polyclonal anti-BRSK2 antibody is suitable to detect BRSK2 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for BRSK2 antibody (AA 250-736) (ABIN7872927)

Target: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRSK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-BRSK2 Antibody

Binding Specificity: AA 250-736

Purpose: BRSK2 Antibody / Brain-selective kinase 2

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M250-P736) was used as the immunogen for the BRSK2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the BRSK2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the BRSK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for BRSK2

Target: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Alternative Name: BRSK2

Background: BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene. BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.

UniProt: Q8IWQ3