IL4 Receptor antibody (AA 26-719)

Catalog No. ABIN7873015

The Rabbit Polyclonal anti-IL4 Receptor antibody (ABIN7873015) specifically detects IL4 Receptor in ELISA, FACS and IHC (p). The antibody is reactive with Mouse and Rat samples.

Quick Overview for IL4 Receptor antibody (AA 26-719) (ABIN7873015)

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL4 Receptor antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL4 Receptor Antibody

Binding Specificity: AA 26-719

Purpose: Il4 receptor Antibody

Purification: Affinity purified

Immunogen: A rat recombinant partial protein (amino acids I26-E719) was used as the immunogen for the Il4 receptor antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Il4 receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Il4 receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Alternative Name: Il4 receptor

Background: IL4R (INTERLEUKIN 4 RECEPTOR) is a human gene that encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. The IL4R gene is localized to 16p12.1-p11.2 by in situ hybridization and Southern blot analysis of DNA from a panel of mouse-human somatic cell lines. IL4 plays a major role in immunoglobulin E(IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL4 receptor. IL4 interacts with IL4R with high affinity, leading to dimerization with either the common gamma chain,a component of receptors for a number of cytokines, to create a type I receptor, or with IL13RA1 to form a type II receptor.The IL4R gene contains 12 exons and IL4R is a complex of at least 2 components, one of which is a novel affinity converting subunit that is critical for cellular signal transduction. See also IL13RA1 and IL13RA2.

UniProt: Q63257

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process