PLAGL2 antibody (AA 269-365)

Catalog No. ABIN7873070

This Rabbit Polyclonal antibody specifically detects PLAGL2 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PLAGL2 antibody (AA 269-365) (ABIN7873070)

Target: PLAGL2 (Pleiomorphic Adenoma Gene-Like 2 (PLAGL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAGL2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-PLAGL2 Antibody

Binding Specificity: AA 269-365

Purpose: PLAGL2 Antibody / Pleiomorphic adenoma gene-like 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human PLAGL2 recombinant protein (Position: K269-E365) was used as the immunogen for the PLAGL2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PLAGL2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PLAGL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PLAGL2

Target: PLAGL2 (Pleiomorphic Adenoma Gene-Like 2 (PLAGL2))

Alternative Name: PLAGL2

Background: PLAGL2 antibody detects Pleiomorphic adenoma gene-like protein 2, a zinc finger transcription factor involved in cell proliferation, differentiation, and tumorigenesis. Encoded by the PLAGL2 gene on chromosome 20q11.21, this nuclear protein belongs to the PLAG family of transcription factors, which regulate gene expression through DNA binding to consensus sequences within promoter regions. PLAGL2 is known for its dual role in promoting stem cell maintenance and activating oncogenic pathways, as well as influencing differentiation and apoptosis depending on cellular context.

Structurally, PLAGL2 contains seven C2H2-type zinc finger domains that enable DNA binding and transcriptional activation of target genes such as IGF2, PAI-1, and NRP1. It interacts with coactivators and chromatin remodeling proteins to modulate gene transcription linked to growth and migration. PLAGL2 contributes to the regulation of Wnt and hypoxia signaling pathways by activating genes involved in angiogenesis and metabolic adaptation.

The PLAGL2 antibody is widely used in cancer biology, developmental biology, and transcriptional regulation research to study gene activation and oncogenic signaling. Western blot analysis typically identifies a 57 kilodalton band corresponding to PLAGL2, while immunofluorescence shows nuclear localization consistent with its role as a transcriptional regulator. This antibody allows investigation of transcriptional networks and regulatory mechanisms controlling cellular transformation and differentiation.

In oncology, PLAGL2 has been implicated in colorectal, lung, and brain cancers where it promotes stem-like characteristics, epithelial-mesenchymal transition, and resistance to apoptosis. Conversely, in certain developmental contexts, PLAGL2 supports normal differentiation by activating lineage-specific genes. The PLAGL2 antibody provides a powerful tool for exploring these complex regulatory roles in tumor and stem cell biology. NSJ Bioreagents validates this antibody for its applications, ensuring dependable detection in transcriptional and cancer signaling studies.

UniProt: Q9UPG8