PDGFB antibody (AA 27-158)

Catalog No. ABIN7873080

The Mouse Monoclonal anti-PDGFB antibody is suitable to detect PDGFB in samples from Human. It has been validated for IHC (p).

Quick Overview for PDGFB antibody (AA 27-158) (ABIN7873080)

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDGFB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PDGFB-3072

Product Details anti-PDGFB Antibody

Binding Specificity: AA 27-158

Purpose: PDGFB Antibody

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 27-158 was used as the immunogen for the PDGFB antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the PDGFB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PDGFB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PDGFB

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Alternative Name: PDGFB

Background: PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains, A and B, and occurs as three isoforms, PDGF AA, AB and BB. The three isoforms bind, with different affinities, to two receptor types, receptors. Evidence suggests that PDGF may function as a neurotrophic factor. Receptors for PDGF-A are expressed in oligodendrocyte progenitor cells whereas receptors for PDGF-B are expressed on neurons. These facts suggest that the different isoforms of PDGF may regulate growth and differentiation of different cell types in the developing central nervous system through paracrine and autocrine routes.

UniProt: P01127

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling