IL-7 antibody (AA 27-177)

Catalog No. ABIN7873090

The Mouse Monoclonal anti-IL-7 antibody (Clone IL7-4269) (ABIN7873090) specifically detects IL-7 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for IL-7 antibody (AA 27-177) (ABIN7873090)

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-7 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL7-4269

Product Details anti-IL-7 Antibody

Binding Specificity: AA 27-177

Purpose: Interleukin-7 Antibody / IL-7

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 27-177) from the mature human protein was used as the immunogen for the Interleukin-7 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the Interleukin-7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Interleukin-7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL-7

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Alternative Name: Interleukin-7

Background: Interleukin-7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor specific chain and the IL-2 receptor gamma chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of Insulin receptor substrate-1 (IRS-1) and Insulin receptor substrate-2 (IRS-2), originally called 4PS.

UniProt: P13232

Pathways: JAK-STAT Signaling