IL-11 antibody (AA 27-61)

Catalog No. ABIN7873137

The Rabbit Polyclonal anti-IL-11 antibody is suitable to detect IL-11 in samples from Human. It has been validated for WB.

Quick Overview for IL-11 antibody (AA 27-61) (ABIN7873137)

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL-11 Antibody

Binding Specificity: AA 27-61

Purpose: IL-11 Antibody (N-Terminal Region)

Purification: Antigen affinity

Immunogen: A portion of amino acids 27-61 from human IL-11 was used as the immunogen for the IL-11 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the IL-11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IL-11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL-11

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Alternative Name: IL-11

Background: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:< a href=http://www.uniprot.org/citations/12919066 target=_blank>12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. [UniProt]

UniProt: P20809

Pathways: JAK-STAT Signaling, Negative Regulation of Hormone Secretion