CD43 antibody (AA 272-400)

Catalog No. ABIN7873162

The Mouse Monoclonal anti-CD43 antibody (Clone 4I3) (ABIN7873162) specifically detects CD43 in FACS, WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CD43 antibody (AA 272-400) (ABIN7873162)

Target: CD43 (SPN) (Sialophorin (SPN))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD43 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4I3

Product Details anti-CD43 Antibody

Binding Specificity: AA 272-400

Purpose: CD43 Antibody

Purification: Affinity purified

Immunogen: A human recombinant protein (amino acids A272-P400) was used as the immunogen for the CD43 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the CD43 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CD43 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CD43

Target: CD43 (SPN) (Sialophorin (SPN))

Alternative Name: CD43

Background: CD43, also known as leukosialin or sialophorin, is a transmembrane cell surface protein that in humans is encoded by the SPN gene. It is mapped to 16p11.2. It is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which is important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome, suggesting that CD43 have a role in T-cell activation. T-cell activation requires the removal of CD43 from the immunologic synapse to allow efficient engagement of the TCR with molecules on the APC.

UniProt: P16150

Pathways: Regulation of Leukocyte Mediated Immunity