Recombinant Mesothelin antibody (AA 273-407)

Catalog No. ABIN7873189

The Rabbit Monoclonal anti-Mesothelin antibody (Clone MSLN-6443R) (ABIN7873189) specifically detects Mesothelin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Mesothelin antibody (AA 273-407) (ABIN7873189)

Target: Mesothelin (MSLN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Mesothelin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MSLN-6443R

Product Details anti-Mesothelin Antibody

Binding Specificity: AA 273-407

Purpose: Recombinant Mesothelin Antibody / MSLN

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 273-407) from the human protein was used as the immunogen for the recombinant Mesothelin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Mesothelin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Mesothelin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Mesothelin

Target: Mesothelin (MSLN)

Alternative Name: Mesothelin

Background: Mesothelin is a 40 kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69 kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process