Recombinant Synaptophysin antibody (AA 274-313)

Catalog No. ABIN7873201

The Rabbit Monoclonal anti-Synaptophysin antibody (Clone SYP-7976R) (ABIN7873201) specifically detects Synaptophysin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Synaptophysin antibody (AA 274-313) (ABIN7873201)

Target: Synaptophysin (SYP)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Synaptophysin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SYP-7976R

Product Details anti-Synaptophysin Antibody

Binding Specificity: AA 274-313

Purpose: Synaptophysin Antibody / SYP

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 274-313) from the human protein was used as the immunogen for the Synaptophysin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Synaptophysin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Synaptophysin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: Synaptophysin

Background: This recombinant rabbit monoclonal antibody recognizes a protein of 38 kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity