RBP4 antibody (AA 29-148)

Catalog No. ABIN7873350

The Mouse Monoclonal anti-RBP4 antibody is suitable to detect RBP4 in samples from Human. It has been validated for IHC (p).

Quick Overview for RBP4 antibody (AA 29-148) (ABIN7873350)

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RBP4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RBP4-4047

Product Details anti-RBP4 Antibody

Binding Specificity: AA 29-148

Purpose: RBP4 Antibody / Retinol Binding Protein 4 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 29-148 from the human protein was used as the immunogen for the RBP4 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the RBP4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the RBP4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for RBP4

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Alternative Name: RBP4

Background: Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

UniProt: P02753

Pathways: Regulatory RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response