HDAC8 antibody (AA 29-347)

Catalog No. ABIN7873415

This Rabbit Polyclonal antibody specifically detects HDAC8 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HDAC8 antibody (AA 29-347) (ABIN7873415)

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HDAC8 Antibody

Binding Specificity: AA 29-347

Purpose: Histone Deacetylase 8 Antibody / HDAC8

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D29-E347) was used as the immunogen for the Histone Deacetylase 8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Histone Deacetylase 8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Histone Deacetylase 8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HDAC8

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Alternative Name: Histone Deacetylase 8

Background: HDAC8, Histone deacetylase 8, is an enzyme that in humans is encoded by the HDAC8 gene, and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Sequence analysis predicted that the 377-amino acid HDAC8 protein contains the 9 conserved HDAC blocks that are presumably important for catalytic function. HDAC8 shares 54 % sequence similarity with HDAC1 and HDAC2 and 39 % similarity with HDAC3, making it a class I HDAC. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.

UniProt: Q9BY41

Pathways: Cellular Glucan Metabolic Process