Dopamine d2 Receptor antibody (AA 307-336)

Catalog No. ABIN7873732

The Rabbit Polyclonal anti-Dopamine d2 Receptor antibody (ABIN7873732) specifically detects Dopamine d2 Receptor in WB. The antibody is reactive with Human samples.

Quick Overview for Dopamine d2 Receptor antibody (AA 307-336) (ABIN7873732)

Target: Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dopamine d2 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Dopamine d2 Receptor Antibody

Binding Specificity: AA 307-336

Purpose: DRD2 Antibody / Dopamine D2 Receptor

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 307-336 from the human protein were used as the immunogen for the DRD2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the DRD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DRD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Dopamine d2 Receptor

Target: Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))

Alternative Name: DRD2

Background: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia, other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

UniProt: P14416

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity