Claudin 18 antibody (AA 31-261)

Catalog No. ABIN7873758

The Rabbit Polyclonal anti-Claudin 18 antibody is suitable to detect Claudin 18 in samples from Human and Rat. It has been validated for WB, ELISA, FACS, IF and IHC (p).

Quick Overview for Claudin 18 antibody (AA 31-261) (ABIN7873758)

Target: Claudin 18 (CLDN18)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 18 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Claudin 18 Antibody

Binding Specificity: AA 31-261

Purpose: Claudin 18 Antibody / CLDN18

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids S31-V261) was used as the immunogen for the Claudin 18 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Claudin 18 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Claudin 18 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Claudin 18

Target: Claudin 18 (CLDN18)

Alternative Name: Claudin 18

Background: Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

UniProt: P56856

Pathways: Cell-Cell Junction Organization, Hepatitis C