T-Box 1 antibody (AA 327-356)

Catalog No. ABIN7873976

This Rabbit Polyclonal antibody specifically detects T-Box 1 in WB, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for T-Box 1 antibody (AA 327-356) (ABIN7873976)

Target: T-Box 1 (TBX1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-T-Box 1 Antibody

Binding Specificity: AA 327-356

Purpose: TBX1 Antibody / T-box protein 1

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 327-356 from the human protein was used as the immunogen for the TBX1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the TBX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TBX1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: TBX1

Background: TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98 % amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

UniProt: O43435

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation