MSH2 antibody (AA 327-427)

Catalog No. ABIN7873977

The Mouse Monoclonal anti-MSH2 antibody is suitable to detect MSH2 in samples from Human. It has been validated for WB, IF, FACS and IHC (p).

Quick Overview for MSH2 antibody (AA 327-427) (ABIN7873977)

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MSH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: MSH2-2622

Product Details anti-MSH2 Antibody

Binding Specificity: AA 327-427

Purpose: MSH2 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 327-427) was used as the immunogen for this MSH2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the MSH2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the MSH2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MSH2

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Alternative Name: MSH2

Background: Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.

UniProt: P43246

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response