ITM2C antibody (AA 33-226)

Catalog No. ABIN7873992

The Rabbit Polyclonal anti-ITM2C antibody is suitable to detect ITM2C in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for ITM2C antibody (AA 33-226) (ABIN7873992)

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-ITM2C Antibody

Binding Specificity: AA 33-226

Purpose: ITM2C Antibody / Integral membrane protein 2C

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human ITM2C recombinant protein (Position: E33-D226) was used as the immunogen for the ITM2C antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ITM2C antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ITM2C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ITM2C

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Alternative Name: ITM2C

Background: ITM2C antibody detects Integral membrane protein 2C, a type II transmembrane protein implicated in neuronal differentiation, amyloid precursor protein (APP) metabolism, and synaptic maintenance. Encoded by the ITM2C gene on chromosome 11q25, this protein belongs to the BRICHOS superfamily, whose members are involved in protein folding, trafficking, and neuroprotection. ITM2C is highly expressed in the central nervous system, particularly in the hippocampus and cerebral cortex, where it contributes to synaptic function and neuroplasticity.

Structurally, ITM2C contains a short cytoplasmic N-terminal tail, a single transmembrane domain, and a large luminal BRICHOS domain that assists in proper folding of amyloidogenic proteins. ITM2C interacts with APP and modulates its processing by influencing the activity of secretases, thereby reducing amyloid beta peptide production. This regulatory function positions ITM2C as a potential protective factor against neurodegenerative diseases such as Alzheimer's disease.

The ITM2C antibody is widely used in neuroscience and neurodegeneration research to study synaptic organization, APP metabolism, and BRICHOS domain biology. Western blot analysis detects a 30 kilodalton band corresponding to ITM2C, while immunofluorescence reveals Golgi and vesicular localization within neurons and glial cells. This antibody supports investigations into the cellular pathways controlling amyloid processing and synaptic stability.

Loss or dysregulation of ITM2C has been associated with cognitive decline and neuroinflammation. Reduced expression leads to impaired APP trafficking and enhanced amyloid accumulation, while overexpression protects against oxidative and excitotoxic stress. Beyond the brain, ITM2C is expressed in pancreatic islets, suggesting additional roles in endocrine regulation. The ITM2C antibody provides a powerful tool for elucidating mechanisms of protein homeostasis and synaptic maintenance in health and disease. NSJ Bioreagents validates this antibody for its applications, ensuring accurate and consistent performance in neurobiology research.

UniProt: Q9NQX7