ANTXR1 antibody (AA 33-301)

Catalog No. ABIN7873996

The Rabbit Polyclonal anti-ANTXR1 antibody (ABIN7873996) specifically detects ANTXR1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ANTXR1 antibody (AA 33-301) (ABIN7873996)

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANTXR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ANTXR1 Antibody

Binding Specificity: AA 33-301

Purpose: TEM8 Antibody / Anthrax toxin receptor / ATR / ANTXR1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids E33-D301) was used as the immunogen for the TEM8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TEM8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TEM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ANTXR1

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Alternative Name: TEM8

Background: Anthrax toxin receptor 1 (ANTXR1 or also known as TEM8) is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

UniProt: Q9H6X2