IL7R antibody (AA 33-433)

Catalog No. ABIN7874001

The Rabbit Polyclonal anti-IL7R antibody is suitable to detect IL7R in samples from Human. It has been validated for FACS, WB, ELISA and IHC (p).

Quick Overview for IL7R antibody (AA 33-433) (ABIN7874001)

Target: IL7R (Interleukin 7 Receptor (IL7R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL7R antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL7R Antibody

Binding Specificity: AA 33-433

Purpose: CD127 Antibody

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids A33-Q433) was used as the immunogen for the CD127 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CD127 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CD127 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for IL7R

Target: IL7R (Interleukin 7 Receptor (IL7R))

Alternative Name: CD127

Background: The interleukin-7 receptor, also known as IL7R alpha, is a protein found on the surface of cells. It is mapped to 5p13. Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).

UniProt: P16871

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size