MSH2 antibody (AA 337-583)

Catalog No. ABIN7874055

The Mouse Monoclonal anti-MSH2 antibody is suitable to detect MSH2 in samples from Human. It has been validated for WB, IF and IHC (p).

Quick Overview for MSH2 antibody (AA 337-583) (ABIN7874055)

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MSH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6B4F7

Product Details anti-MSH2 Antibody

Binding Specificity: AA 337-583

Purpose: MSH2 Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human MSH2 protein (amino acids Q337-N583) was used as the immunogen for the MSH2 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the MSH2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MSH2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MSH2

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Alternative Name: MSH2

Background: DNA mismatch repair protein Msh2, also known as MutS protein homolog 2 or MSH2, is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2 which forms a heterodimer with MSH6 to make the human MutS-alpha mismatch repair complex. It also dimerizes with MSH3 to form the MutS-beta DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair. It has been found that MSH2 may also be a coactivator of ESR1-dependent gene expression.

UniProt: P43246

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response