SIM2 antibody (AA 337-609)

Catalog No. ABIN7874056

The Rabbit Polyclonal anti-SIM2 antibody (ABIN7874056) specifically detects SIM2 in ELISA, WB and FACS. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for SIM2 antibody (AA 337-609) (ABIN7874056)

Target: SIM2 (Single-Minded Homolog 2 (SIM2))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIM2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-SIM2 Antibody

Binding Specificity: AA 337-609

Purpose: SIM2 Antibody / Single-minded homolog 2 / BHLHE15

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids Y337-R609) was used as the immunogen for the SIM2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SIM2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SIM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SIM2

Target: SIM2 (Single-Minded Homolog 2 (SIM2))

Alternative Name: SIM2

Background: Single-minded homolog 2 is a protein that in humans is encoded by the SIM2 gene. This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

UniProt: Q14190