CEACAM1 antibody (AA 34-382)

Catalog No. ABIN7874078

This Rabbit Polyclonal antibody specifically detects CEACAM1 in WB, FACS, ICC, ELISA and IF. It exhibits reactivity toward Rat and Mouse.

Quick Overview for CEACAM1 antibody (AA 34-382) (ABIN7874078)

Target: CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEACAM1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)

Product Details anti-CEACAM1 Antibody

Binding Specificity: AA 34-382

Purpose: Ceacam1 Antibody / Carcinoembryonic antigen-related cell adhesion molecule 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived mouse Ceacam1 recombinant protein (Position: A34-D382) was used as the immunogen for the Ceacam1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Ceacam1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Ceacam1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CEACAM1

Target: CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))

Alternative Name: Ceacam1

Background: CEACAM1 antibody targets Carcinoembryonic antigen-related cell adhesion molecule 1, a transmembrane glycoprotein that mediates cell-cell adhesion, signal transduction, and immune regulation. The CEACAM1 gene belongs to the CEA family within the immunoglobulin superfamily and encodes multiple isoforms with long or short cytoplasmic tails. CEACAM1 is broadly expressed on epithelial cells, endothelial cells, and subsets of leukocytes, including activated T and B cells, natural killer cells, and neutrophils. The protein functions as both an adhesion molecule and an immune checkpoint regulator, participating in inhibitory signaling via its immunoreceptor tyrosine-based inhibitory motifs (ITIMs) present in the long cytoplasmic domain.

CEACAM1 contributes to numerous physiological processes including tissue morphogenesis, angiogenesis, and modulation of inflammatory responses. Its expression at intercellular junctions facilitates homophilic and heterophilic interactions with other CEACAM family members, supporting epithelial integrity. In immune cells, CEACAM1 engagement downregulates T-cell activation and cytokine release, serving as a negative regulator of immune responses. Dysregulation of CEACAM1 signaling has been implicated in autoimmune disorders, infectious disease susceptibility, and tumor immune evasion. In cancer biology, CEACAM1 acts context-dependently: it may function as a tumor suppressor by maintaining epithelial polarity, yet also contributes to tumor metastasis and angiogenesis in certain malignancies.

The human CEACAM1 gene is located on chromosome 19q13.2 and spans over 9 exons. Its expression is transcriptionally controlled by cytokines such as interferon gamma and transforming growth factor beta, reflecting its integration into immune regulatory networks. Pathogen binding studies have shown that CEACAM1 serves as an entry receptor for several bacteria, including Neisseria species and Haemophilus influenzae, making it a target of interest in host-pathogen interaction research.

Immunohistochemical staining using CEACAM1 antibody demonstrates strong expression in liver, lung, and intestinal epithelia, with variable detection in tumors such as melanoma, colorectal carcinoma, and prostate cancer. CEACAM1 antibody from NSJ Bioreagents provides a valuable reagent for investigating epithelial differentiation, immune checkpoint biology, and cancer progression mechanisms.

UniProt: P31809