ITGA8 antibody (AA 347-964)

Catalog No. ABIN7874121

The Rabbit Polyclonal anti-ITGA8 antibody is suitable to detect ITGA8 in samples from Human. It has been validated for WB, ELISA, FACS and IF.

Quick Overview for ITGA8 antibody (AA 347-964) (ABIN7874121)

Target: ITGA8 (Integrin alpha-8 (ITGA8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-ITGA8 Antibody

Binding Specificity: AA 347-964

Purpose: Integrin alpha 8 Antibody / ITGA8

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E347-D964) was used as the immunogen for the Integrin alpha 8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Integrin alpha 8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Integrin alpha 8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ITGA8

Target: ITGA8 (Integrin alpha-8 (ITGA8))

Alternative Name: Integrin alpha 8

Background: Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: P53708