LDLR antibody (AA 35-843)

Catalog No. ABIN7874181

The Rabbit Polyclonal anti-LDLR antibody is suitable to detect LDLR in samples from Human and Rat. It has been validated for WB, ELISA, FACS and IHC (p).

Quick Overview for LDLR antibody (AA 35-843) (ABIN7874181)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LDLR Antibody

Binding Specificity: AA 35-843

Purpose: LDL Receptor Antibody / LDLR

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids Q35-D843) was used as the immunogen for the LDL Receptor antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LDL Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LDL Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDL Receptor

Background: In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism