KRT14 antibody (AA 351-472)

Catalog No. ABIN7874234

This Mouse Monoclonal antibody specifically detects KRT14 in FACS and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KRT14 antibody (AA 351-472) (ABIN7874234)

Target: KRT14 (Keratin 14 (KRT14))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KRT14 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: KRT14-2375

Product Details anti-KRT14 Antibody

Binding Specificity: AA 351-472

Purpose: Cytokeratin 14 Antibody / KRT14 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 351-472) was used as the immunogen for this Cytokeratin 14 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Cytokeratin 14 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Cytokeratin 14 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for KRT14

Target: KRT14 (Keratin 14 (KRT14))

Alternative Name: Cytokeratin 14

Background: Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.

UniProt: P02533