KRT14 antibody (AA 351-472)

Catalog No. ABIN7874235

The Mouse Monoclonal anti-KRT14 antibody is suitable to detect KRT14 in samples from Human, Mouse and Rat. It has been validated for FACS and IHC (p).

Quick Overview for KRT14 antibody (AA 351-472) (ABIN7874235)

Target: KRT14 (Keratin 14 (KRT14))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KRT14 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KRT14-2375

Product Details anti-KRT14 Antibody

Binding Specificity: AA 351-472

Purpose: Cytokeratin 14 Antibody / KRT14

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 351-472) was used as the immunogen for this Cytokeratin 14 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Cytokeratin 14 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Cytokeratin 14 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for KRT14

Target: KRT14 (Keratin 14 (KRT14))

Alternative Name: Cytokeratin 14

Background: Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.

UniProt: P02533