MSH6 antibody (AA 357-388)

Catalog No. ABIN7874275

The Rabbit Polyclonal anti-MSH6 antibody (ABIN7874275) specifically detects MSH6 in WB, IF, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for MSH6 antibody (AA 357-388) (ABIN7874275)

Target: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSH6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Product Details anti-MSH6 Antibody

Binding Specificity: AA 357-388

Purpose: MSH6 Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D357-H388) was used as the immunogen for the MSH6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MSH6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MSH6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MSH6

Target: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Alternative Name: MSH6

Background: MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

UniProt: P52701

Pathways: DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response