CNTNAP2 antibody (AA 363-1159)

Catalog No. ABIN7874334

The Rabbit Polyclonal anti-CNTNAP2 antibody is suitable to detect CNTNAP2 in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for CNTNAP2 antibody (AA 363-1159) (ABIN7874334)

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNTNAP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CNTNAP2 Antibody

Binding Specificity: AA 363-1159

Purpose: CASPR2 Antibody / CNTNAP2

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids N363-E1159) was used as the immunogen for the CASPR2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CASPR2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CASPR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CNTNAP2

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Alternative Name: CASPR2

Background: Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5 % of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability.

UniProt: Q9UHC6