Retinoblastoma Binding Protein 4 antibody (AA 365-424)

Catalog No. ABIN7874340

The Rabbit Polyclonal anti-Retinoblastoma Binding Protein 4 antibody is suitable to detect Retinoblastoma Binding Protein 4 in samples from Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for Retinoblastoma Binding Protein 4 antibody (AA 365-424) (ABIN7874340)

Target: Retinoblastoma Binding Protein 4 (RBBP4)

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Retinoblastoma Binding Protein 4 Antibody

Binding Specificity: AA 365-424

Purpose: Zebrafish Rbbp4 Antibody / Retinoblastoma-binding protein 4

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Rbbp4 recombinant protein (amino acids E365-Q424) was used as the immunogen for the Zebrafish Rbbp4 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Rbbp4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Rbbp4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Retinoblastoma Binding Protein 4

Target: Retinoblastoma Binding Protein 4 (RBBP4)

Alternative Name: Rbbp4

Background: Zebrafish Rbbp4, also known as retinoblastoma binding protein 4, is a chromatin associated protein that plays a crucial role in regulating gene expression by modifying chromatin structure. It is a member of the WD40 repeat protein family and is involved in the assembly and function of multiple chromatin remodeling and histone deacetylase complexes. Rbbp4 contributes to nucleosome remodeling and histone modification, processes that are essential for transcriptional regulation, DNA replication, and cell cycle progression.

Zebrafish Rbbp4 is an ortholog of the human RBBP4 protein, with a high level of sequence and functional conservation. The protein interacts with histone H4 and serves as a core component of complexes such as the nucleosome remodeling and deacetylase complex, also known as the NuRD complex. Through these interactions, Rbbp4 plays a vital role in controlling the accessibility of DNA for transcription factors and other regulatory proteins.

At present, there is no evidence of multiple isoforms of zebrafish Rbbp4 being identified, in contrast to some other chromatin associated proteins. Research on Rbbp4 in zebrafish provides insights into its roles during development, as chromatin remodeling is critical for processes such as cell differentiation, axis formation, and organ development.

Antibodies targeting zebrafish Rbbp4 protein are important tools for studies in epigenetic regulation, histone dynamics, and developmental biology. Given its orthology to human RBBP4, zebrafish Rbbp4 serves as a valuable model to study conserved mechanisms of chromatin remodeling and transcriptional regulation.

UniProt: Q6P3H7

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus