PDP antibody (AA 37-537)

Catalog No. ABIN7874408

This Rabbit Polyclonal antibody specifically detects PDP in WB, ELISA, FACS and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PDP antibody (AA 37-537) (ABIN7874408)

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-PDP Antibody

Binding Specificity: AA 37-537

Purpose: PDP1 Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids S37-E537) was used as the immunogen for the PDP1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PDP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PDP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PDP

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Alternative Name: PDP1

Background: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

UniProt: Q9P0J1