HTR2C antibody (AA 372-458)

Catalog No. ABIN7874430

The Rabbit Polyclonal anti-HTR2C antibody is suitable to detect HTR2C in samples from Human and Rat. It has been validated for WB and ELISA.

Quick Overview for HTR2C antibody (AA 372-458) (ABIN7874430)

Target: HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTR2C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HTR2C Antibody

Binding Specificity: AA 372-458

Purpose: 5-HT2C Receptor Antibody / HTR2C

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids N372-V458) was used as the immunogen for the 5-HT2C Receptor antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the 5-HT2C Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the 5-HT2C Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HTR2C

Target: HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))

Alternative Name: 5-HT2C Receptor

Background: This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.

UniProt: P28335

Pathways: Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour