Melanoma gp100 antibody (AA 376-502)

Catalog No. ABIN7874471

This Mouse Monoclonal antibody specifically detects Melanoma gp100 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Melanoma gp100 antibody (AA 376-502) (ABIN7874471)

Target: Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Melanoma gp100 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: MSSG95-2

Product Details anti-Melanoma gp100 Antibody

Binding Specificity: AA 376-502

Purpose: Melanoma gp100 Antibody / PMEL17 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 376-502 from the human protein was used as the immunogen for the Melanoma gp100 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Melanoma gp100 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Melanoma gp100 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Melanoma gp100

Target: Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))

Alternative Name: Melanoma gp100

Background: PMEL17/Melanoma gp100/SILV plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. [UniProt]

UniProt: P40967