Desmoglein 3 antibody (AA 379-491)

Catalog No. ABIN7874487

The Mouse Monoclonal anti-Desmoglein 3 antibody is suitable to detect Desmoglein 3 in samples from Human. It has been validated for ELISA.

Quick Overview for Desmoglein 3 antibody (AA 379-491) (ABIN7874487)

Target: Desmoglein 3 (DSG3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmoglein 3 antibody is un-conjugated

Application: ELISA

Clone: DSG3-2796

Product Details anti-Desmoglein 3 Antibody

Binding Specificity: AA 379-491

Purpose: Desmoglein 3 Antibody / DSG3

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 379-491) was used as the immunogen for the Desmoglein 3 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Desmoglein 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Desmoglein 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Desmoglein 3

Target: Desmoglein 3 (DSG3)

Alternative Name: Desmoglein 3

Background: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

UniProt: P32926