TMEM201 antibody (AA 38-591)

Catalog No. ABIN7874512

The Rabbit Polyclonal anti-TMEM201 antibody (ABIN7874512) specifically detects TMEM201 in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for TMEM201 antibody (AA 38-591) (ABIN7874512)

Target: TMEM201 (Transmembrane Protein 201 (TMEM201))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM201 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-TMEM201 Antibody

Binding Specificity: AA 38-591

Purpose: TMEM201 Antibody / Transmembrane protein 201

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TMEM201 recombinant protein (Position: R38-R591) was used as the immunogen for the TMEM201 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TMEM201 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TMEM201 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TMEM201

Target: TMEM201 (Transmembrane Protein 201 (TMEM201))

Alternative Name: TMEM201

Background: TMEM201 Antibody is used to study Transmembrane protein 201, an inner nuclear membrane protein that helps organize the nuclear envelope and coordinate nucleus-to-cytoskeleton communication. Localized at the inner nuclear membrane, Transmembrane protein 201 interacts with elements of the LINC complex that connect nuclear lamins to actin cables, supporting nuclear positioning, cell polarization, and directed migration. By anchoring the nucleus to retrograde actin flow through transmembrane actin-associated nuclear lines, Transmembrane protein 201 influences how cells orient and move in response to external cues, a process relevant to development, wound repair, and vascular remodeling.

Biochemically, Transmembrane protein 201 contains luminal and cytoplasmic regions that permit associations with lamins and cytoskeletal adaptors. These interactions help maintain nuclear envelope integrity and may tune mechanotransduction, allowing cells to translate mechanical forces into gene-regulatory outcomes. Perturbation of Transmembrane protein 201 can disrupt centrosome orientation and impair cell polarity, emphasizing its role at the interface of structure and signaling. In endothelial systems, increased Transmembrane protein 201 activity has been linked with enhanced migration during angiogenic sprouting, underscoring its relevance to vascular biology.

Researchers use TMEM201 Antibody to define inner nuclear membrane architecture by immunofluorescence, co-localize the protein with lamins or SUN/KASH components, and quantify expression under conditions that alter cytoskeletal tension. In immunoblotting, the antibody detects endogenous Transmembrane protein 201 and can monitor isoform abundance or post-translational changes across cell states. Immunoprecipitation with TMEM201 Antibody enables mapping of protein partners at the nuclear envelope, supporting studies that connect nuclear mechanics to transcriptional control and cell fate decisions. Because nuclear positioning and mechanosensitive signaling influence differentiation, immunity, and cancer invasion, this reagent supports a wide set of experimental questions.

The TMEM201 Antibody from NSJ Bioreagents provides dependable performance across imaging and biochemical workflows, allowing laboratories to standardize detection in side-by-side studies of nuclear envelope organization, polarized migration, and endothelial biology. In development models, it can reveal how nuclear anchorage guides morphogenesis, in pathobiology, it helps test whether altered nuclear-cytoskeletal coupling contributes to invasive behavior or impaired tissue repair. For teams integrating live-cell imaging, traction force microscopy, or RNA-seq, pairing functional assays with precise localization data from this antibody can clarify how structural changes at the inner nuclear membrane shape downstream transcriptional programs.

As interest grows in how nuclear architecture governs cell behavior, TMEM201 Antibody provides a practical bridge between nuclear envelope structure and systems-level outcomes. Its use in standard immunocytochemistry, tissue immunohistochemistry, and pulldown experiments makes it a versatile tool for dissecting nuclear positioning, mechanotransduction, and angiogenesis, while helping connect biophysical cues to gene regulation and phenotype in both normal physiology and disease contexts.

TMEM201 Antibody supports rigorous inquiries into nuclear mechanics with a single, reliable probe that integrates cleanly into multicolor imaging, gel-based quantification, and interactome discovery workflows.

UniProt: Q5SNT2