Desmoglein 3 antibody (AA 384-957)

Catalog No. ABIN7874537

This Rabbit Polyclonal antibody specifically detects Desmoglein 3 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for Desmoglein 3 antibody (AA 384-957) (ABIN7874537)

Target: Desmoglein 3 (DSG3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoglein 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Desmoglein 3 Antibody

Binding Specificity: AA 384-957

Purpose: DSG3 Antibody / Desmoglein 3

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R384-Q957) was used as the immunogen for the DSG3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DSG3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the DSG3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Desmoglein 3

Target: Desmoglein 3 (DSG3)

Alternative Name: DSG3

Background: Desmoglein3 is also known as PVA(Pemphigus Vulgaris Antigen). Pemphigus vulgaris(PV) and pemphigus foliaceus(PF) are autoimmune diseases of the skin which have as target antigens 2 different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen(PVA, or desmoglein-3) in the case of PV and desmoglein I in the case of PF. The DSG3 gene, like the genes for DSG1 and DSG2, is located on chromosome 18. The human DSG3 gene consists of 15 exons and spans more than 23 kb. DSG3 and DSG1 are the autoantigens of pemphigus vulgaris and pemphigus foliaceus, respectively. DSG3 and DSG1 are the target antigens in PNP, and IgG autoantibodies against DSG3 in PNP sera play a pathogenic role in the loss of keratinocyte adhesion and blistering.

UniProt: P32926