SOCS5 antibody (AA 386-536)

Catalog No. ABIN7874548

The Rabbit Polyclonal anti-SOCS5 antibody (ABIN7874548) specifically detects SOCS5 in WB, ELISA and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SOCS5 antibody (AA 386-536) (ABIN7874548)

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SOCS5 Antibody

Binding Specificity: AA 386-536

Purpose: SOCS5 Antibody / Suppressor of cytokine signaling 5

Purification: Antigen affinity purified

Immunogen: Amino acids M386-K536 from the human protein were used as the immunogen for the SOCS5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SOCS5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SOCS5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SOCS5

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Alternative Name: SOCS5

Background: SOCS5 (Suppressor of cytokine signaling 5) is a member of the SOCS family, a group of intracellular proteins that function as negative regulators of cytokine receptor signaling. SOCS5 contains an SH2 domain and a SOCS box motif, allowing it to interact with activated receptors and associated kinases to modulate JAK-STAT pathway activity. By preventing excessive cytokine signaling, SOCS5 maintains immune system balance and contributes to cellular homeostasis. A SOCS5 antibody is a valuable tool for investigating these regulatory mechanisms.

SOCS5 has been implicated in the regulation of interleukin and growth factor signaling. Its activity helps control cell proliferation, differentiation, and survival. Aberrant expression or dysfunction of SOCS5 has been associated with various pathological conditions, including chronic inflammation, autoimmune disorders, and certain cancers. Using a SOCS5 antibody enables researchers to evaluate its expression patterns, molecular interactions, and role in disease development.

In addition to its role in immune regulation, SOCS5 has been shown to influence neural development and epithelial cell signaling, highlighting its multifunctional nature. Studies have indicated that SOCS5 can act as a tumor suppressor in specific contexts, while in other cases, it may contribute to oncogenesis depending on the signaling environment. Employing a SOCS5 antibody allows for precise characterization of these complex roles across different biological systems.

NSJ Bioreagents offers a high-quality SOCS5 antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Selecting a SOCS5 antibody from NSJ Bioreagents ensures reliable performance for studies of cytokine signaling, immune regulation, and cancer biology.

UniProt: O75159

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process