GLUD1 antibody (AA 40-539)

Catalog No. ABIN7874704

The Rabbit Polyclonal anti-GLUD1 antibody (ABIN7874704) specifically detects GLUD1 in WB and IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for GLUD1 antibody (AA 40-539) (ABIN7874704)

Target: GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLUD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GLUD1 Antibody

Binding Specificity: AA 40-539

Purpose: Zebrafish Glud1 Antibody / Glud1a / Glud1b / Glutamate dehydrogenase

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Glud1a/b recombinant protein (amino acids S40-A539) was used as the immunogen for the Zebrafish Glud1 antibody. This antibody will detect the a and b isoforms.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Glud1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Glud1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GLUD1

Target: GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))

Alternative Name: Glud1

Background: This gene encodes Glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.

UniProt: Q6NZ29

Pathways: Positive Regulation of Peptide Hormone Secretion, Warburg Effect