GBP1 antibody (AA 400-592)

Catalog No. ABIN7874732

This Mouse Monoclonal antibody specifically detects GBP1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for GBP1 antibody (AA 400-592) (ABIN7874732)

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GBP1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GBP1-7618

Product Details anti-GBP1 Antibody

Binding Specificity: AA 400-592

Purpose: GBP1 Antibody / Guanylate binding protein 1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 400-592) from the human protein was used as the immunogen for the GBP1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GBP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GBP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GBP1

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Alternative Name: GBP1

Background: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin