CYBB antibody (AA 416-527)

Catalog No. ABIN7874906

This Rabbit Polyclonal antibody specifically detects CYBB in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for CYBB antibody (AA 416-527) (ABIN7874906)

Target: CYBB (Cytochrome B-245, beta Polypeptide (CYBB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYBB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-CYBB Antibody

Binding Specificity: AA 416-527

Purpose: NOX2/gp91phox Antibody / CYBB

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids F416-H527) was used as the immunogen for the NOX2/gp91phox antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NOX2/gp91phox antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NOX2/gp91phox antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CYBB

Target: CYBB (Cytochrome B-245, beta Polypeptide (CYBB))

Alternative Name: NOX2/gp91phox

Background: NOX2 (NADPH OXIDASE 2), also called CYBB (CYTOCHROME b(-245), BETA SUBUNIT), p91-PHOX or GP91-1, is a human gene encoding a glycoprotein. NOX2 is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. It is mapped on Xp11.4. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes. As a major player in innate immune responses in neutrophils, NOX2 is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling).

UniProt: P04839