HSD17B8 antibody (AA 42-244)

Catalog No. ABIN7874918

This Rabbit Polyclonal antibody specifically detects HSD17B8 in WB, ELISA and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HSD17B8 antibody (AA 42-244) (ABIN7874918)

Target: HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-HSD17B8 Antibody

Binding Specificity: AA 42-244

Purpose: HSD17B8 Antibody / 17-beta-hydroxysteroid dehydrogenase 8

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D42-D244) was used as the immunogen for the HSD17B8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HSD17B8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the HSD17B8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HSD17B8

Target: HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8))

Alternative Name: HSD17B8

Background: Estradiol 17 beta-dehydrogenase 8, also called 17-beta-HSD 8 and Protein Ke6, is an enzyme that in humans is encoded by the HSD17B8 gene. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.

UniProt: Q92506

Pathways: Steroid Hormone Biosynthesis