STOML2 antibody (AA 43-293)

Catalog No. ABIN7874961

The Rabbit Polyclonal anti-STOML2 antibody is suitable to detect STOML2 in samples from Human, Mouse and Rat. It has been validated for WB, IHC, ELISA, IP and FACS.

Quick Overview for STOML2 antibody (AA 43-293) (ABIN7874961)

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STOML2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Product Details anti-STOML2 Antibody

Binding Specificity: AA 43-293

Purpose: STOML2 Antibody / Stomatin-like protein 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human STOML2 recombinant protein (Position: Q43-S293) was used as the immunogen for the STOML2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STOML2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STOML2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STOML2

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Alternative Name: STOML2

Background: STOML2 antibody detects Stomatin-like protein 2, encoded by the STOML2 gene. Stomatin-like protein 2 is a mitochondrial inner membrane protein involved in mitochondrial organization, respiratory chain activity, and apoptosis regulation. STOML2 antibody provides researchers with a specific reagent for studying mitochondrial function, metabolic regulation, and cell death pathways.

Stomatin-like protein 2 belongs to the stomatin family of membrane-associated proteins, which share a conserved stomatin domain. Research using STOML2 antibody has shown that it localizes to mitochondria, where it regulates the stability of respiratory chain complexes. By supporting the assembly of complex I and complex IV, STOML2 ensures efficient oxidative phosphorylation and ATP production.

Studies with STOML2 antibody have revealed that it also participates in apoptosis regulation. Overexpression of Stomatin-like protein 2 enhances resistance to apoptotic stimuli, while depletion sensitizes cells to cell death. This suggests that STOML2 balances mitochondrial function with survival pathways, making it an important regulator of cellular fate under stress conditions.

Dysregulation of STOML2 expression has been linked to cancer. Research using STOML2 antibody has demonstrated that elevated expression supports tumor cell survival, proliferation, and migration by maintaining mitochondrial energy metabolism. High STOML2 expression correlates with poor prognosis in several cancers, including breast and gastric cancer. These findings emphasize its potential as a biomarker and therapeutic target.

Stomatin-like protein 2 also contributes to immune function. Studies with STOML2 antibody have suggested that it regulates T cell activation and cytokine production by influencing mitochondrial metabolism. This highlights its role in integrating energy metabolism with immune responses, broadening its functional relevance.

STOML2 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies mitochondrial protein expression, immunohistochemistry demonstrates expression in tissues with high energy demand, and immunofluorescence highlights colocalization with mitochondrial markers. These applications make STOML2 antibody indispensable for mitochondrial research.

By providing validated STOML2 antibody reagents, NSJ Bioreagents supports studies into mitochondrial biology, metabolism, and cancer. Detection of Stomatin-like protein 2 provides researchers with insight into how mitochondrial proteins regulate bioenergetics and cell survival.

UniProt: Q9UJZ1

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection