GRM2 antibody (AA 439-710)

Catalog No. ABIN7875001

The Rabbit Polyclonal anti-GRM2 antibody (ABIN7875001) specifically detects GRM2 in WB, ELISA, IHC (p) and FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for GRM2 antibody (AA 439-710) (ABIN7875001)

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-GRM2 Antibody

Binding Specificity: AA 439-710

Purpose: GRM2 Antibody / Metabotropic Glutamate Receptor 2

Purification: Affinity purified

Immunogen: A human recombinant protein (amino acids N439-A710) was used as the immunogen for the GRM2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GRM2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GRM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GRM2

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Alternative Name: GRM2

Background: Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: Q14416

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport