PDIA3 antibody (AA 446-475)
Quick Overview for PDIA3 antibody (AA 446-475) (ABIN7875047)
Target
See all PDIA3 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 446-475
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Purpose
- Protein disulfide-isomerase A3 Antibody / PDIA3 / ERp57
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Purification
- Purified
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Immunogen
- A portion of amino acids 446-475 from the human protein was used as the immunogen for the Protein disulfide-isomerase A3 antibody.
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Isotype
- Ig Fraction
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Application Notes
- The stated application concentrations are suggested starting points. Titration of the Protein disulfide-isomerase A3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Aliquot the Protein disulfide-isomerase A3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))
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Alternative Name
- Protein disulfide-isomerase A3
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Background
- PDIA3 is the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase, however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
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UniProt
- P30101
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Pathways
- Maintenance of Protein Location, Protein targeting to Nucleus, Cell RedoxHomeostasis
Target
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