SOX4 antibody (AA 45-130)

Catalog No. ABIN7875055

The Mouse Monoclonal anti-SOX4 antibody (Clone PCRP-SOX4-1D6) (ABIN7875055) specifically detects SOX4 in WB, IHC (p), IF and FACS. The antibody is reactive with Human samples.

Quick Overview for SOX4 antibody (AA 45-130) (ABIN7875055)

Target: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOX4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-SOX4-1D6

Product Details anti-SOX4 Antibody

Binding Specificity: AA 45-130

Purpose: SOX4 Antibody

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 45-130 was used as the immunogen for the SOX4 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the SOX4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the SOX4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SOX4

Target: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Alternative Name: SOX4

Background: SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF--induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

UniProt: Q06945